Resveratrol Supplements May Improve Bone Density in Men

Resveratrol, an antioxidant found in red wine, has gained a following for its possible age-slowing benefits. In a new study, Danish researchers reported that high doses of resveratrol appear to improve bone density.

Marie Juul Ornstrup, MD, PhD, and her colleagues at Aarhus University Hospital tested the effects of two doses of resveratrol and placebos on 66 obese men with metabolic syndrome. Some of the men took 1,000 mg of resveratrol while others took only 150 mg.

Men taking the higher dose of resveratrol benefited from significant increases in bone alkaline phosphatase and bone mineral density. Bone alkaline phosphatase is involved in mineralization.

Ornstrup wrote that the resveratrol supplements “positively affects bone, primarily by stimulating formation of mineralization.”


Ornstrup MJ, Harslof T, Nordstrom T, et al. Resversatol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism, 2014; 99:4720-9.

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