Supplements for Children's Brain Health

Supplements for Optimal Focus and Concentration - Nutrients to Maximize a Child’s Full Brain Potential

Behavior problems, including an inability to stay focused and pay attention, have become prevalent in school-age children. Often, children are treated with prescription drugs to improve behavior, which not only have serious side effects, but are also suspected of creating long-lasting negative changes in the structure and function of the brain.[1] If a child’s behavior is interfering with his or her life at school or home, there is a problem that needs to be addressed. This can include poor concentration, inattentiveness, difficulty maintaining normal academic progress, or excessive fidgetiness. One thing is clear; prescription drugs are not the only way to resolve these issues.

What’s Behind the Behavior Problems?

Ultimately, it is best to focus on supporting a child’s brain so that they can reach their maximum potential. The best place to start is to look at the possible triggers to misbehavior and attention troubles. One of the foundational concepts that must be addressed when looking at the underlying cause of these issues is nutrition. Besides nutrient insufficiencies, other factors that may contribute to the inability to focus are adrenal fatigue or thyroid dysfunction.25Overgrowth of unfriendly organisms in the intestinal system, like candida, is another possible trigger.[2] Numerous studies have also confirmed a strong relationship between childhood learning disabilities and body stores of heavy metals, particularly lead.[3] Other environmental stresses or pollutants can also impact learning and behavior.[4]

On the Road to Full Brain Potential 

Healing must begin with a nourishing diet; however, when deficiencies and imbalances are present, therapeutic doses of nutrients are instrumental. Furthermore, it is almost impossible to take in all the nutrients one needs through foods with the typical American diet. This is where supplementation comes in. The first supplement that should be considered is a high potency multiple vitamin and mineral. This provides a wide range of nutrients that help protect the brain from free radical damage and inflammation and supports the body’s production of neurotransmitters–vital brain messengers like serotonin that are responsible for learning and behavior. One study found that when school-age children (6 to 12) with behavioral problems supplemented with a multi-vitamin, they had much better control over antisocial behaviors, such as swearing, vandalism, assault, and refusal to work.[5] Another study published in the Alterative Medicine Review found a supplement program (a mixture of vitamins, minerals, amino acids, essential fatty acids, and probiotics) to be as effective as Ritalin for a group of children with ADHD.[6]

In addition to a multiple vitamin and mineral, other nutrients can be used to maximize a child’s brain potential. There are many available products and formulas geared toward children that are tasty and easy to take. Below is a detailed description of the nutrients backed by scientific research for supporting focus, attention, positive behavior, and brain function in children.

Essential fatty acids (EFAs)

Essential fatty acids (EFAs), namely EPA and DHA, are one of the most important nutrient groups when it comes to supporting the brain.[7],[8],[9] These special fats arefound primarily in fish oil and fish liver—foods children tend to not consume in abundance. A deficiency in EFAs is being identified as a factor in behavior and attention problems.[10],[11],[12],[13] EFAs influence behavior by supporting intestinal permeability and the proper development of brain tissue.[14] In a 12-week, double-blind study, children with ADHD were given either a placebo or a fatty acid supplement providing daily: 186 mg of EPA, 480 mg of DHA, 96 mg of gamma-linolenic acid (GLA), 864 mg of linoleic acid, and 42 mg of arachidonic acid. Compared with the placebo, the fatty acid supplement produced significant improvements in both cognitive function and behavioral problems with no adverse effects.[15]Up to one tablespoon of a liquid per daycan be taken,[16] depending on weight and individuality. Be sure to supplement at least 100 mg/day of DHA.17


Magnesium is another common deficiency in children with behavior and attention problems.[17] One study found that 95% of 116 kids with ADHD were deficient in this calming mineral.29In another trial, children with ADHD and low magnesium status were given 200 mg/per day for six months. Those taking the mineral had a significant decrease in hyperactive behavior compared to those who did not receive the nutrient.[18]


Iron helps regulate the activity of dopamine, a neurotransmitter synthesized by the adrenal glands and intricately involved in behavior and concentration. Researchers evaluated 14 ADHD boys between the ages of seven and 11 for the effect of short-term iron administration on behavior. Each boy received 5 mg/kg body weight of iron daily for 30 days. In the end, the parents believed the children’s behavior improved.[19] Iron, the most absorbable “heme” form, is found abundantly in meat, poultry, and fish.


Zinc is an important cofactor for producing the brain supportive neurotransmitters, like serotonin and dopamine, and other brain substances involved in learning, focus, and attention. A zinc deficiency has also been linked to attention problems.[20] One study showed that ADHD children had less than half the levels of zinc than the non-ADHD control group.[21] Copperneeds to be taken with zinc to prevent imbalance.4Foods high in zinc include pumpkin seeds, meats, eggs, and seafood.

Vitamin C and proanthocyanidins

Vitamin C and proanthocyanidins (found in grape seed extract) are essential for several brain functions. Vitamin C is needed to manufacture neurotransmitters, and to protect the brain from free radical damage.24Proanthocyanidins enhance the effects of vitamin C and modify enzymatic activities particular to the brain.[22]  Proanthocyanidins also encourage dopamine activity in the brain, which can help with focus and concentration.[23]

B vitamins

B vitamins are involved in assisting brain enzymes in using carbohydrates for energy, helping synthesize neurotransmitters such as serotonin, dopamine, and GABA, and forming the myelin shields between brain neurons. B1 (thiamin) deficiency is known to contribute to nervousness and irritability. Deficient levels of vitamin B6, which causes low serotonin levels, have also been detected in children with attention problems.[24]

Phosphatidylserine (PS)

Phosphatidylserine (PS) is a fat-soluble phospholipid and a key component of all cell membranes, but is found in particularly high concentrations in the brain. This nutrient is extracted from lecithin, and is found in foods such as soy and eggs. PS is gaining recognition as a focus and attention-supporting nutrient due to its role in benefiting a wide range of brain functions.[25] It supports neurotransmitter production (namely dopamine) and maintains nerve connections. In a study where a group of 27 ADHD children took 200 to 300 mg of PS daily for four months, researchers found that 25 children exhibited improvement in learning capacity and behavior with no adverse affects.[26],[27],[28]

Additional Brain Boosters to Consider


Probiotics, the friendly bacteria naturally found in the intestinal tract, may need to be enhanced in children with attention issues. Brain functioncan be influenced by dysbiosis, which occurs when there is an overgrowth of unfriendly organisms in the intestinal system and an absence of the beneficial. This imbalance is encouraged by the use of antibiotics, which often destroys the good bacteria along with the bad. The average child undergoes multiple courses of antibiotic treatment in the first five years of life, typically without replacement of probiotics. The resulting overgrowth of yeast and other pathogenic flora has been linked to alterations of immune function, food sensitivities, and behavior. In addition to supplementation, another good way to support the friendly bacteria is to consume fermented foods like plain yogurt, kefir, miso, and raw sauerkraut.

Amino acids

Amino acids, the building blocks of protein, are essential for the production of neurotransmitters (e.g. serotonin and dopamine), which are crucial for maintaining healthy brain function. Children with attention problems are often deficient in L-glutamine, a precursor for gamma-aminobutyric acid (GABA), a neurotransmitter that calms the mind and may play a role in hyperactivity.[29],[30] GABA supplementation itself has also been shown to be helpful.5Tyrosine supplementation has been shown to increase dopamine concentration dramatically and produce impressive anti-stress[31] and pro-concentration results.[32],[33]


DMAE (Dimethylaminoethanol) accelerates the brain’s production of acetylcholine, a substance that plays a role in the brain’s nerve impulse transmission. DMAE is naturally found in brain foods like anchovies and sardines. It has been used effectively to support attention, learning and behavior, and motor coordination.[34]


Choline, a precursor for acetylcholine, is another possible nutrient to consider for maintaining brain health. One study found that poor memory and developmental instability correlated with lower concentrations of choline-containing compounds.[35]


5-HTP (5-hydroxytryptophan)is a precursor for serotonin, a brain neurotransmitter involved in learning and behavior. Researchers have found that blood levels of serotonin tend to be lower in children with more severe symptoms of hyperactivity, impulsiveness, aggressiveness, and lack of concentration.[36]

Stress-reducing herbs

Stress-reducing herbs, such as passion flower, valerian, or lemon balm, may be appropriate because stress may contribute to behavior problems.[37] A study of a combination herbal product containing American ginseng extract (200 mg) and Ginkgo biloba extract (50 mg) found that between 31 to 74 percent of those taking the herbs experienced improvements in shyness, social problems, hyperactivity, and impulsiveness.[38]


Algae, such as spirulina, has also been suggested to help with attention and behavior problems. Spirulina may help by removing aluminum and other toxins from the body.[39],[40] This food supplement also contains amino acids and other easy-to-absorb nutrients. One study found an 81 percent improvement in academic scores when children took one gram of spirulina every day for six months.[41] In another study using one gram of blue-green algae daily for 10 weeks with 109 children, most of the children showed significant improvement in their ability to focus, concentrate, and follow directions.29

As you can see, there are many natural choices when dealing with behavior and learning challenges. It is imperative for parents to look at all the possible contributing causes and be a health detective. Be sure to provide plenty of healthy foods and well-designed meals, and supplant TV and video games with exercise and outdoor activities. Finally, consider your supplement options and choose what will offer your child the best opportunity to reach their maximum brain potential – naturally!

This article is strictly educational and not meant to replace a physician’s recommendations. It is best to talk with a doctor if you are taking medications before trying to incorporate or substitute any of the above options.



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[3]Pizzorno, Joseph N.D. and Murray, Michael N.D. Textbook of Natural Medicine. 2ndEd. 2000.

[4]Balch, James. M.D. Prescription for Nutritional Healing. Avery Publishing. 2000.

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[6]Harding, Karen, PhD. et al. Outcome-based Comparison of Ritalin vs. Food-Supplement Treated Children with AD/HD. Altern Med. Rev. 2003;8(3):319-330.

[7]Gibson R.A., Neumann M.A., Makrides M.  Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants.  Lipids 1996; 31:  S177-S93.

[8]Mitchell E.A., Aman M.G., Turbott S.H. Clinical characteristics and serum essential fatty acid levels in hyperactive children.  Clin Pediatr 1987 Aug: 26(8):  406-11

[9]Stevens L.J., Zentall S.S., Deck J.L., Abate M.L., et al.  Essential fatty acid metabolism in boys with attention deficit hyperactivity disorder.  Am J Clin Nutr 1995 Oct; 62(4):  761-8

[10]Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr 1987;26:406–11.

[11]Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62:761–8.

[12]Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr 1987;26:406–11

[13]Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62:761–8

[14]Burgess JR, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr. Jan2000;71(1 Suppl):327S-30S.

[15]Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:233–9

[16]Germano, Carl, RD, CNS, The Brain Wellness Plan, Kensington Books, Copyright 1997.

[17]Starobrat-Hermelin B. The effect of deficiency of selected bioelements on hyperactivity in children with certain specified mental disorders. Ann Acad Med Stetin. 1998:297-314.

[18]Starobrat-Hermelin, B., Kozielec, T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnesium Res. 1997; 10(2): 149-56

[19]Sever Y, et al. Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report. Neuropsychobiology 1997;35(4):178-80.

[20]Toren P. Eldar S, Sela BA, et al.  Zinc deficiency in attention-deficit hyperactivity disorder.  Biol Psychiatry. 1996;40:1308-1310.

[21]Bekaroglu M, et al. Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note. J Child Psychol Psychiatry 1996 Feb;37(2):225-7.

[22]Roger CR. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 1988 Sep 15;44(9):724-804.

[23]Ross, Julia, M.A. The Mood Cure. Viking. 2002

[24]Bhagavan HN, Coleman M, Coursin DB. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics 1975;55:437–41.

[25]Kidd, PM. A review of five nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-161

[26]Kidd, P.M. Phosphatidylserine: the nutrient that accelerates all brain functions and counters Alzheimer’s disease: Keats Pub. 1998.

[27]O’Brien, C., “Answers to ADD,” Vitamin Retailer, March 2002.

[28]Jorisse, B.L., Brouns, F., Van Boxtel, M.P., Ponds, R.W., Verhey, F.R., Jolles, J., Riedel, W.J. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr. Neurosci. 2001; 4(2): 121-34.

[29]Carlsson, M.L. On the role of cortical glutamate in obsessive-compulsive disorder and attention-deficit hyperactivity disorder, two phenomenologically antithetical conditions. Acta Psychiatr. Scand. 2000 Dec; 102(6): 401-13; erratum, Acta Psychiatr. Scand. 2001 Jul; 104(1): 80

[30]Arnold, L.E. Alternative treatments for adults with attention-deficit hyperactivity disorder. Ann. N.Y. Acad. Sci. 2001 Jun; 931: 310-41.

[31]Lehnert H, et al. Neurochemical and behavioral consequences of acute, uncontrollable stress: Effects of dietary tyrosine. Brain Res 1984;303:215-23.

[32]Ross, Julia, M.A. The Mood Cure. Viking. 2002.

[33]Amen, Daniel, M.D. Healing ADD. New York: Putnam, 2001.

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[35]Yeo, R.A., Hill, D., Campbell, R., Vigil, J., Brooks, W.M. Developmental instability and working memory ability in children: a magnetic resonance spectroscopy investigation. Dev. Neuropsychol. 2000; 17(2): 143-59

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[38]Lyon, M.R., Cline, J.C., Totosy de Zepetnek, J., Shan, J.J., Pang, P., Benishin, C. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J. Psychiatry Neurosci. 2001 May; 26(3): 221-8

[39]Torres-Duran, P.V., Miranda-Zamora, R., Paredes-Carbajal, M.C., Mascher, D., Diaz-Zagoya, J.C., Juarez-Oropeza, M.A. Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat. Biochem. Mol. Biol. Int. 1998; 44: 787-93

[40]Vadiraja, B.B., Gaikwad, N.W., Madyastha, K.M. Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicity in rats. Biochem. Biophys. Res. Commun. 1998; 249: 428-31

[41]Sevulla, I., Aguiree, N. Study on the Effects of Super Blue Green Algae 1995. Managua, Nicaragua: Universidad Centro Americano